Abstract #1081

Validation of Susceptibility Mapping for Quantification of Iron in Subcortical Grey Matter in Multiple Sclerosis

Hongfu Sun¹, Andrew Walsh¹, R. Marc Lebel¹, Gregg Blevins², Ingrid Catz², Jian-Qiang Lu³, Edward Johnson³, Derek Emery⁴, Kenneth Warren², Alan H. Wilman¹

¹Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada; ²Division of Neurology, University of Alberta, Edmonton, Alberta, Canada; ³Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada; ⁴Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada

Brain iron accumulation occurs in multiple sclerosis (MS). Validating MRI measurements of brain iron requires postmortem study. We compare in situ postmortem quantitative susceptibility mapping (QSM) to Perls iron staining in MS subjects. High correlations were found between QSM and Perls' iron stain optical density.