Katherine A. Koenig1,
Ken E. Sakaie1, Mark J. Lowe1, Jian Lin1,
Lael Stone2, Robert A. Bermel3, Erik B. Beall1,
Stephen M. Rao2, Bruce D. Trapp4, Micheal D. Phillips1
1Imaging
Sciences, Cleveland Clinic, Cleveland, OH, United States; 2Neurological
Institute, Cleveland Clinic, Cleveland, OH, United States; 3Neurological
Institute, The Cleveland Clinic, Cleveland, OH, United States; 4Neurosciences,
Cleveland Clinic, Cleveland, OH, United States
The current study compares hippocampal atrophy to episodic memory measures and to diffusion measures of the fornix in patients with Multiple Sclerosis. Though we find no differences in overall hippocampal volume between patients and controls, measures of white matter integrity in the fornix and a measure of episodic memory were related to hippocampal volume only in patients. This bolsters the argument that hippocampal pathology contributes to memory loss in MS.