Li Yao1, Su Lui1, Fei Li1, Xun Yang1, Godfrey Pearlson2, Matcheri Keshavan3, Carol Tamminga4, Qiyong Gong1, John Sweeney4
1Department of Radiology, Huaxi MR Research Center, Chengdu, Sichuan, China; 2Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, United States; 3Beth Israel Deaconness Medical Center, Boston, MA, United States; 4Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States
Although the schizophrenia and bipolar disorder share a number of overlap in clinical features, they are conceptualized as separate disease, and it is still uncertainty about the common and distinct neural substrates of each. Fifty-three schizophrenia patients, sixy-seven bipolar disorder patients and fifty-nine normal controls were scanned with resting-state functional MRI on a 3T. Regional low-frequency BOLD signal oscillations were used to identified regional functional deficits in these patients. Our findings revealed that the regional functional deficits of the two disease are quite different and involving two different neural network.