William D. Rooney1,
Manoj K. Sammi1, John Grinstead1, 2, Jim
Pollaro1, Audrey H. Selzer1, Xin Li1,
Charles Springer1
1Advanced
Imaging Research Center, Oregon Health & Science University, Portland,
OR, United States; 2Siemens Healthcare USA, Malverne, PA, United
States
Contrast reagents (CR) find widespread use in MRI and an important consideration in ultra-high field MRI relates to CR detection sensitivity. The purpose of this study was to quantify the detection sensitivity of a low molecular weight gadolinium based CR at 3T and 7T in human head tissue. Twelve subjects were studied at 3T and 7T using a dynamic contrast enhanced MRI protocol with quantitative measurement of tissue water proton longitudinal relaxation rate constants. We find significantly better CR detection sensitivity at 7T compared to 3T.