M. Ayaz Khan1, 2, Jie Liu1, 2, Jaladhar Neelavalli3, 4, Saifeng Liu5, Ewart Mark Haacke3, 5, Rong Zhang1, 2
1Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Institute for Exercise and Environmental Medicine, Dallas, TX, United States; 3Biomedical Engineering Department, Wayne State University, Detroit, MI, United States; 4Radiology, Wayne State University, Detroit, MI, United States; 5Biomedical Engineering Department, McMaster University, Hamilton, Ontario, Canada
Brain oxygen saturation is a key parameter for assessing oxygen supply, metabolism and tissue viability. Near infrared spectroscopy is a widely used technique to measure brain tissue oxygen saturation. However, this technique cannot be used to measures brain tissue oxygenation in deep brain structures and could be contaminated by changes in extracranial tissue oxygenation. Susceptibility weighted image mapping generates susceptibility maps which can be used to measure oxygen saturation in local venous structures in the brain. This study compared measurements of brain oxygen saturation using susceptibility mapping and near infrared spectroscopy in normal healthy subjects.