Elaine L. Bearer1, 2, Joseph J. Gallagher2, Aaron Gonzales3, XiaoWei Zhang2, Russell E. Jacobs4
1Pathology, University of New Mexico, Health Sciences Center, Albuquerque, NM, United States; 2Biology, California Institute of Technology, Pasadena, CA, United States; 3Pathology, University of New Mexico, Health Sciences Center, Abuquerque, NM, United States; 4Beckman Institute, California Institute of Technology, Pasadena, CA, United States
Transport defects impact neuronal survival. We are developing and applying high-field MEMRI to detect and measure transport dynamics in living mouse models of neurodegenerative diseases. Here we present results from the aged double transgenic mice expressing human mutant amyoid precursor protein under control of the Tet-off promotor. Statistical parametric mapping and ROI analyses demonstrate decreased Mn2+ accumulation in the contralateral hippocampus and the medial septal nuclei in the forebrain after injection in the right hippocampus in aged versus young mice which is exacerbated with in the APP over-expressors who also display numerous Abeta plaques.