Lydia Wachsmuth1, Thomas Seidenbecher2, Thomas Budde2, Cornelius Faber1
1Clinical Radiology, Experimental NMR, University Hospital Mnster, Mnster, Germany; 2Clinical Radiology, Experimental NMR, Westflische Wilhelms University, Mnster, Germany
In this study we used Manganese-enhanced MRI (MEMRI) to investigate local accumulation pattern of manganese after systemic, fractionated administration by T1 weighted imaging and T1 mapping in a genetic rat model of human absence epilepsy, the Genetic Absence Epilepsy rats from Strasbourg (GAERS). We found slight, but significantly reduced T1 relaxation times within the somatosensory cortex of GAERS rat, but no significant differences within other structures of the thalamocortical network when compared to nonepileptic controls. Rather small T1 relaxation reducing effects indicate that systemic administration of manganese is not sufficient and intracranial application has to be performed in future studies.