1Radiology, Northwestern University, Chicago, IL, United States; 2Biomedical Engineering, Northwestern University, Chicago, IL, United States; 3Division of Cardiac Surgery, Northwestern University, Chicago, IL, United States; 4Department of Medicine, Laval University, Quebec, Canada
Valve aortic stenosis (AS) is the most common cause of valvular replacement. The AS severity is mainly evaluated by transthoracic Doppler echocardiography (TTE) by measuring transvalvular velocity gradients and valve effective orifice area (EOA). In particular, valve EOA has high variability when measured by TTE. 3D time-resolved phase contrast MRI with 3-directional velocity encoding may improve EOA estimation by leveraging the advantages of a novel jet shear layer detection (JSLD) method for estimating valve EOA. The objective of this study was to validate 4D flow MRI-based EOA estimation using an in-vitro stenosis phantom and in-vivo measurements of the JSLD-determined EOA.