Christopher A. Miller1,
2, Josephine H. Naish1, Glyn Coutts3, David Clark4,
Sha Zhou1, Geoffrey J. M. Parker1, Matthias Schmitt,
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1Centre
for Imaging Sciences & Biomedical Imaging Institute, University of
Manchester, Manchester, United Kingdom; 2North West Heart Centre and
The Transplant Centre, University Hospital of South Manchester, Manchester,
United Kingdom; 3Christie Medical Physics and Engineering, The
Christie Hospital, Manchester, United Kingdom; 4Alliance Medical
Cardiac MRI Unit, Manchester, United Kingdom
This study provides whole-heart, histological validation of; 1. Dynamic-equilibrium cardiovascular magnetic resonance (DynEq-CMR), where myocardial extracellular volume (ECV) is quantified using hematocrit-adjusted myocardial and blood T1 values measured before and after gadolinium bolus; and 2. Isolated measurement of myocardial T1 at a fixed time-point following gadolinium bolus, used as an ECV surrogate.