Christopher A. Miller1, 2, Josephine H. Naish1, Glyn Coutts3, David Clark4, Sha Zhou1, Geoffrey J. M. Parker1, Matthias Schmitt, 12
1Centre for Imaging Sciences & Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom; 2North West Heart Centre and The Transplant Centre, University Hospital of South Manchester, Manchester, United Kingdom; 3Christie Medical Physics and Engineering, The Christie Hospital, Manchester, United Kingdom; 4Alliance Medical Cardiac MRI Unit, Manchester, United Kingdom
This study provides whole-heart, histological validation of; 1. Dynamic-equilibrium cardiovascular magnetic resonance (DynEq-CMR), where myocardial extracellular volume (ECV) is quantified using hematocrit-adjusted myocardial and blood T1 values measured before and after gadolinium bolus; and 2. Isolated measurement of myocardial T1 at a fixed time-point following gadolinium bolus, used as an ECV surrogate.