1Biomedical Engineering, University of Virginia, Charlottesville, VA, United States; 2Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States; 3Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 4Medicine, Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, United States; 5Xemed LLC, Durham, NH, United States; 6Physics, University of New Hampshire, Durham, NH, United States
The characteristics of the red blood cell (RBC) and tissue/plasma components of hyperpolarized xenon-129 dissolved in the human lung are not well established. The purpose of this study was to determine, from whole-lung measurements, the fractions and T2* values for the RBC and tissue/plasma components for healthy and diseased subjects, and explore their dependence on degree of lung inflation. In healthy subjects, RBC fraction and T2*, and tissue/plasma T2*, showed little variation among subjects. RBC fraction and tissue/plasma T2* were found to depend on lung inflation. RBC fraction was significantly lower in the diseased subjects than in healthy subjects.