Alexandra R. Morgan1, 2, Geoff J. M. Parker1, 2, Penny L. Hubbard1, Weijuan Zhang1, David Singh3, Jrgen Vestbo3, Simon S. Young4, Lars Wigstrm5, Marietta L.J. Scott4, Josephine H. Naish1
1Centre for Imaging Sciences, Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom; 2BiOxyDyn Ltd, Manchester, United Kingdom; 3Airway Pharmacology Group, School of Translational Medicine, University Hospital of South Manchester, Manchester, United Kingdom; 4AstraZeneca, Alderley Park, Macclesfield, United Kingdom; 5AstraZeneca, Mlndal, Sweden
Proton MRI methods calculating regional strain, compliance and motion in the lung were applied in a reproducibility study in a cohort of COPD (chronic obstructive pulmonary disease) patients and healthy volunteers. Correlation with computed tomography and spirometry was also investigated. Significant differences between patients and healthy volunteers were observed, as well as fair inter-visit reproducibility. Significant correlation of compliance and strain with gold standard measures was shown, suggesting clinically useful observations can be made using these methods.