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Abstract #1505

in vitro and in vivo 19-Fluorine Magnetic Resonance Imaging (MRI) of β-Cells and Pancreatics Using GLUT-2 Specific Contrast Agents

Sayuan Liang1, Hauke Kolster1, Karim Louchami2, Tom Dresselaers1, Willy Malaisse2, Sonu Sharma1, Uwe Himmelreich3

1Biomedical MRI unit/MoSAIC, Department of Imaging and Pathology, K.U.Leuven, Leuven, Belgium; 2Laboratory of Experimental Hormonology, Universit Libre de Bruxelles, Bruxelles, Belgium; 3Biomedical MRI unit/MoSAIC, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium


The purpose of this project is to validate β-cell and pancreatic islet imaging by using fluorinated, GLUT2 targeting mannoheptulose derivatives (FMH) in vivo. We have established a