Frank G. Zllner1, Fabian Zimmer1, Sarah Klotz2, Simone Hoeger2, Lothar R. Schad1
1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Wrttemberg, Germany; 2Department of Medicine V, University Medical Centre Mannheim, Heidelberg University, Mannheim, Baden-Wrttemberg, Germany
The assessment of kidney function by measuring renal microvascular perfusion is crucial to diagnose and treat renal diseases like acute kidney injury (AKI). MRI provides two techniques to assess renal perfusion: Dynamic contrast-enhanced (DCE)-MRI and arterial spin labelling (ASL). DCE-MRI involves the injection of a contrast agent to measure the renal blood flow (RBF). Recently, feasibility of DCE-MRI and ASL in a model of acute kidney injury was shown . In this work, we compared a deconvolution analysis and a dedicated 2 compartment filtration model for DCE-MRI quantification. Further we compared also both methods with ASL perfusion. This study showed that ASL and DCE-MRI provide significantly different values for the perfusion of healthy kidneys and kidneys with ischaemic AKI. This shows that all methods are capable of distinguishing the hypoperfusion of a kidney with AKI from the perfusion of a healthy kidney.