Zaheer Akhtar1, David J. Niles2, Omeed Hafez3, Daniela Cornejo2, Shannon Raye Reese3, Nancy Ann Schlei3, Sean B. Fain2, Arjang Djamali3, Elizabeth A. Sadowski1
1Radiology, University of Wisconsin Madison, Madison, WI, United States; 2Medical Physics, University of Wisconsin Madison, Madison, WI, United States; 3Nephrology, University of Wisconsin Madison, Madison, WI, United States
Recent studies have linked the use of Cyclosporin A (CsA) to end stage renal disease in solid organ transplant patients. Understanding the underlying mechanisms of CsA nephrotoxicity would allow for possible therapeutic strategies to be identified. The Nox2 enzyme has been shown to play an important role in CsA induced nephrotoxicity. Renal oxygenation and kidney function were analyzed using BOLD MRI and BUN analysis respectively in wildtype and Nox2 null mice treated with CsA. Preliminary results with BOLD oxygenation measurements and BUN analysis show expected changes upon treatment of CsA in Nox2 null mice.