Jonatan A. Snir1,
Christy Willert2, Gregory A. Dekaban3, 4,
Paula Foster5
1Department
of Medical Biophysics, Robarts Research Institute, London, Ontario, Canada; 2BioTherapeutics
Research Laboratory, Robarts Research Institute, London, Ontario, Canada; 3BioTherapeutics
Research Laboratory, Robarts Research Institute, London, On, Canada; 4Department
of Microbiology and Immunology, Western University, London , Ontario, Canada;
5Imaging Research Laboratories, Robarts Research Institute,
London, Ontario, Canada
Contrast-enhanced MRI has been increasingly used in pre-clinical and clinical studies for improving the diagnostic accuracy of detecting the sentinel lymph node (LN) and differentiating benign from metastatic disease. In this study we explored the use of Gadofluorine M (GFM) for the enhancement of murine LNs and compared the contrast enhancement due to GFM to the more conventional Gd-DTPA (Magnevist) via two routes of administration. GFM proved to be a superior CA for LN imaging. A special consideration, unlike other studies, of the nature of CA enhancement seen in normal LN was further examined.