David A. Hormuth, II1, 2, Nkiruka C. Atuegwu2, Thomas E. Yankeelov1, 2
1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States; 2Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States
Sequential diffusion weighted MRI (DW-MRI), dynamic contrast enhanced MRI (DCE-MRI), and 18F-FDG-PET data of 6 Sprague-Dawley rats implanted with C6 tumors were incorporated into a mathematical model of tumor growth. Two partial differential equations describing the time dependent changes of tumor cell number and glucose concentration were initialized with imaging data. Initial tumor cell number, diffusion, and proliferation were calculated from DW-MRI data, while the initial glucose distributions were estimated from FDG-PET distributions. Delivery of glucose was estimated using DCE-MRI parameters. The calculated and experimentally estimated number of cells and tumor volume were then compared.