Xiaobing Fan1, Kay Macleod1, Suzanne Conzen1, Erica Markiewicz1, Marta Zamora1, James Vosicky1, Devkumar Mustafi1, Gregory S. Karczmar1
1University of Chicago, Chicago, IL, United States
Correlation of in-vivo with ex-vivo whole body MRI of mouse mammary glands is reported. High resolution T2-weighted spin echo images and diffusion weighted images of the polyoma middle T oncoprotein mouse model were acquired in-vivo and ex-vivo at 9.4T. Fiducial markers were used to correlate features on in-vivo and ex-vivo images. The results demonstrate parallels between in-vivo and ex-vivo ADCs; this suggests that ex-vivo images can serve as a guide to improve diffusion weighted imaging. In addition, the registration method shown here will ultimately be used to co-register in-vivo images with histology, using ex-vivo images as a bridge.