Abstract #1761

Significant Increases in Contrast Arrival Time Measured with DCE-MRI Are Seen After Treatment with an Anti-VEGF Agent

Matthew R. Orton¹, Matthew Gwilliam¹, Christina Messiou², David John Collins¹, Veronica A. Morgan², Helen Young³, Nandita M. De Souza¹, Martin O. Leach¹

¹CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research, Sutton, Surrey, United Kingdom; ²Radiology Department, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; ³AstraZeneca, Macclesfield, Cheshire, United Kingdom

This observational report describes statistically significant increases in the contrast arrival time measured using DCE-MRI in a cohort of patients with liver metastases after 1 week and 4 weeks of treatment with an anti-VEGF agent. This result highlights the importance of acquiring data with adequate temporal sampling rates, and the use of robust methods of arrival time estimation when deriving DCE-MRI parameters.