Shih-Chieh Lin1, Chun-Wei Chen1, Chen-Hua Wu1, Chung-Hsin Wang1, Shih-Tsung Kang1, Chih-Kuang Yeh1, Wen-Shiang Chen2, 3, Hsu-Hsia Peng1
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, Taiwan; 2Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan, Taiwan; 3Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan, Taiwan
Transmitting focus ultrasound (FUS) with usage of microbubbles (MBs) has been used to increase blood-brain barrier permeability. In this study, the HASTE sequence was performed to real-time monitor the inertial cavitation effect of MBs. At the onset of inertial cavitation, strong turbulence was produced in solutions. Therefore, with performing HASTE sequence, it was difficult to refocus signals and thus signal drops were revealed. Under the conditions of diluted MBs and acquisitions with different slice thicknesses, substantial signal drops were still observable at the very beginning of FUS transmission, suggesting the feasibility of applying this scheme for in vivo experiments.