Meser M. Ali1, Nadimpalli RS Verma1, Janic Branislava1, James R. Ewing2, Robert A. Knight2, Ali S. Arbab1
1Radiology, Henry Ford Hospital, Detroit, MI, United States; 2Neurology, Henry Ford Hospital, Detroit, MI, United States
Water soluble membrane peptide (pHLIP) is conjugated with anionic dendrimer-based paramagnetic nanoparticle. pHLIP-tagged nanoparticles bind to and are internalized by breast cancer cells in vitro. Systemic delivery of dendrimer-based nanoparticles lead to accumulation of the nanoparticles in a flank mouse model of breast cancer that are detected by optical and MR imaging.