Michael Peller1, Martin Hossann2, Zulfiya Syunyaeva2, Rolf D. Issels2, Maximilian F. Reiser1, Lars H. Lindner2
1Institute for Clinical Radiology, University Hospital Munich, Ludwig-Maximilians University,, Mnchen, Germany; 2Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians University, Mnchen, Germany
Thermosensitive liposomes (TSL) with encapsulated contrast agents (CA) have been proposed for MRI-assisted thermotherapy in tumors. For such purpose an effective temperature induced r1-relaxivity change and stability in the presence of serum components is needed. Here, temperature induced r1 change of 6 approved Gd-based CAs comprising diverse chemical structures and charges encapsulated in phosphatidyldiglycerol (DPPG2)-TSL were characterized. The shelf life of TSL was also investigated.