Samuel Maritim1, Daniel Coman2, 3, Yuegao Huang2, Majura Hoque2, Fahmeed Hyder2, 4
1Diagnostic radiology, Yale University, New Haven, CT, United States; 2Diagnostic Radiology, Yale University, New Haven, CT, United States; 3Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, United States; 4Biomedical Engineering, Yale University, New Haven, CT, United States
Conventional T1 and T2 contrast agents offer great tissue contrast. To go beyond shades of gray in typical molecular/cellular MRI, we developed a new ultra-high speed 3D chemical shift imaging (CSI) method called Biosensor Imaging of Redundant Deviation in Shifts (BIRDS), which requires that we detect protons emanating from the agent (e.g., TmDOTP5-), itself instead of the agents effect on water proton relaxation times. Here we show how resilient BIRDS can be for pH and temperature mapping, specifically when TmDOTP5- is in presence of high concentrations of typical T1 and T2 agents and even when TmDOTP5- inside in liposomes.