Dirk Graafen1, 2, Jan Falk Dechent1, 2, Michael Ryan Hansen2, Kerstin Mnnemann2, Hans Wolfgang Spiess2, Laura Maria Schreiber1
1Department of Radiology, Johannes Gutenberg University Medical Center, Mainz, Germany; 2Max Planck Institute for Polymer Research, Mainz, Germany
Aim of this study was to realize transfer of 1H hyperpolarization to 13C in a clinical MRI system utilizing parahydrogen induced polarization (PHIP). The transfer was achieved by a modified refocused INEPT sequence (PH-INEPT+) which was sequentially transmitted since most clinical MRI systems are only equipped with a single RF transmitter channel. The generated hyperpolarized 13C state for natural abundance hydroxyethylpropionate was used for MRI employing the RARE sequence with 64 images acquired in the echo train. A single acquisition of an image yielded an SNR of 13 that could be increased to 40 by averaging in the echo train.