1Radiology / Medical Physics, University Medicine, Mainz, Germany; 2Max Planck Institute for Polymerresearch, Mainz, Germany; 3Department of Chemistry, University of York, York, United Kingdom; 4York Neuroimaging Centre, York, United Kingdom
Despite the interesting applications of hyperpolarized contrast agents, all suffer from their limited T1 time (hetero and proton nuclei) and most techniques can only be applied to small sample volumes in a batch mode. Here, a combination of the SABRE proton hyperpolarization method (Signal Amplification By Reversible Exchange) together with the use of hollow fiber membranes is presented. The circular flow setup allows for a continuous generation of proton hyperpolarization and a fast transport from the membrane module into the detection chamber. Large signal enhancements can be observed over a period 12 hours.