Evelien M. Barendse1, Albert P. Aldenkamp1, Roy PC Kessels2, Marc P.H. Hendriks2, Geert Thoonen1, Paul A.M. Hofman3, Walter H. Backes3, Jacobus F.A. Jansen3
1Epilepsy Centre Kempenhaeghe, Heeze, NB, Netherlands; 2Neuropsychology, Radboud University Nijmegen, Nijmegen, Ge, Netherlands; 3Radiology, Maastricht University Medical Center, Maastricht, Li, Netherlands
In this cross-sectional study, we investigate the effect of age and intelligence on occipital metabolite concentrations in adolescents (aged 13-19y) with high functioning autism (HFA) and healthy controls. We observed that 1H-MRS provides evidence of atypical membrane metabolism development in HFA, which potentially underlies the observed atypical behavioral development in autism.