Evelien M. Barendse1,
Albert P. Aldenkamp1, Roy PC Kessels2, Marc P.H.
Hendriks2, Geert Thoonen1, Paul A.M. Hofman3,
Walter H. Backes3, Jacobus F.A. Jansen3
1Epilepsy
Centre Kempenhaeghe, Heeze, NB, Netherlands; 2Neuropsychology,
Radboud University Nijmegen, Nijmegen, Ge, Netherlands; 3Radiology,
Maastricht University Medical Center, Maastricht, Li, Netherlands
In this cross-sectional study, we investigate the effect of age and intelligence on occipital metabolite concentrations in adolescents (aged 13-19y) with high functioning autism (HFA) and healthy controls. We observed that 1H-MRS provides evidence of atypical membrane metabolism development in HFA, which potentially underlies the observed atypical behavioral development in autism.