Benot Michel Schaller1, Lijing Xin2, Kieran O'brien3, Rolf Gruetter4
1Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland; 2Department of Radiology, University of Lausanne, Lausanne, Vaud, Switzerland; 3Centre d'Imagerie BioMdicale, University of Geneva, Geneva 14, Geneva, Switzerland; 4Laboratory of Functional and Metabolic Imaging, cole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland
Functional Magnetic Resonance Spectroscopy (fMRS) allows to investigate the small metabolite changes (<0.2mol/g) following a physiological stimulation, by acquiring continuously MR spectra, and provides direct insights into brain metabolism. In this study, a group analysis revealed an increase of [Lac] of 283% and of [Glu] 31% during motor activation.This study establishes that it is possible to investigate the neurochemical profile changes during motor activation. [Lac] and [Glu] increase as has been observed during visual stimulation.