Kathrin Lorenz1, Toralf Mildner1, Andr Pampel1, Harald E. Mller1
1Nuclear Magnetic Resonance Unit, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Saxony, Germany
Inflow vascular-space-occupancy (iVASO) is a non-invasive method for the quantification of absolute arterial cerebral blood volume (aCBV). The present work is purposed to investigate determining factors of aCBV measurement like slow inflow of inverted blood from small vessels and inflow of fresh, i.e. non-inverted, blood in case of short arterial transit times. Transient effects related to the blood delivery by vessels of variable size were addressed by dedicated experiments. Such effects potentially lead to biased values in the aCBV measurement and were shown to vary between different regions in the human brain.