Jack T. Skinner1, 2, Ryan K. Robison2, 3, Christopher C. Quarles1, 2
1Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States; 2Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 3Philips Healthcare, Highland Heights, OH, United States
Previous single-echo techniques for perfusion imaging have been extended to multiple-echo sequences to acquire more accurate estimates of R2* with contrast injection. Recently, a spin- and gradient-echo (SAGE) acquisition, for simultaneous R2 and R2* mapping, was introduced. This current study implements a single-shot SAGE sequence that utilizes SENSE parallel imaging and partial k-space sampling, allowing short echo times (< 10ms) suitable for AIF characterization. Validation of the current protocol with conventional multiple-echo acquisitions was carried out in phantoms and in the brain. The suggested single-shot SAGE acquisition may provide a robust method for quantitative perfusion imaging in brain tumors.