Georges Hankov1, Jill Fredrickson1, Gregory Ferl1, David Clayton1, Alexandre Coimbra2, Alexandre de Crespigny2
1Genentech Inc., South San Francisco, CA, United States; 2Genentech Inc, South San Francisco, CA, United States
The use of DCE-MRI in multicenter therapeutic trials requires standardization, streamlined processing, and a focus on reproducibility. The purpose of this work was to assess the necessity of modeling the AIF and estimating the time lag between tissue and AIF uptake, and also evaluated the reproducibility of the Signal Difference [SD] method, using simulations and patient data. We found that modeling the AIF results in underestimation of the parameters, especially plasma volume, vp. Estimating the time lag increases vp estimates, without altering the other kinetic parameters. The simpler [SD] method was slightly more reproducible than the regular apparent concentration method.