Chih-Feng Chen1, Ho-Ling Liu2, 3, Yu-Jie Huang4, Yuan-Hsiung Tsai1, Hsu-Huei Weng1
1Department of Radiology, Chang Gung Memorial Hospital, Chiayi branch, and Chang Gung University of Science and Technology, Chiayi, Taiwan; 2Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan; 3Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; 4Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
This study assessed heterogeneity changes in peak enhancement ratio (PER) from DCE-MRI by calculating entropy in brain tumors before and after radiotherapy. There were 11 patients in the non-responder group and 12 patients in the responder group. The post- to pre-radiotherapy ratio of entropy was defined as therapeutic entropy ratio (TER). TER was significantly higher in the non-responder (1.140.14) than that in the responder (0.860.1). The corresponding area under the receiver operating characteristic curve was 0.98. In conclusion, calculating the heterogeneity changes in tumors via entropy could help diagnose response to therapy in clinical.