Ze Wang1,
2, Anish Mitra3, Marcus Raichle3, Anna Rose
Childress1, John A. Detre, 24
1Dept.
of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States; 2Dept.
of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 3Neurology,
Washington University in St Louis, St. Louis, MO, United States; 4Dept.
of Neurology, University of Pennsylvania, Philadelphia, PA, United States
Entropy is a measure of system orderliness, and can be assessed as a quantitative brain status index. Using a large resting fMRI database, we systematically investigated resting brain entropy regarding its age and gender effects, spatial distribution, regional organization, and the hierarchical structure of local BEN communities. In this abstract, we showed high test-retest reproducibility of BEN mapping using resting state fMRI in the whole brain. We also showed a clear BEN contrast between the neocortex versus non-neocortex regions in the resting brain.