Abstract #2264

Magnetic Resonance Imaging the Genetic Influence on Intrinsic Resting-State Connectivity in Brown Norway and Dahl Salt-Sensitive Rat Brains

Zhixin Li¹, B. Douglas Ward², Melinda R. Dwinell³, Christopher P. Pawela¹

¹Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee, WI, United States; ²Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; ³Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI, United States

We address for the first time the genetic influences on intrinsic neural connectivity in a resting-state fMRI study of two genetically different inbred rat strains:Brown Norway(BN) and Dahl salt-sensitive(SS) rats.SS rat exhibited differential intrinsic functional connectivity patterns in primary somatosensory and caudate putamen network in comparison to BN rats. These task-specific regional differences in neural network can speculatively suggest an endophenotype or imaging marker of genetic component of under specific biological events.