Neele Saskia Hbner1, 2, Anna Mechling1, Hsu-Lei Lee1, Jrgen Hennig1, Dominik von Elverfeldt1, Laura-Adela Harsan1
1Department of Radiology - Medical Physics, University Medical Center Freiburg, Freiburg, Germany; 2Faculty of Biology, University of Freiburg, Freiburg, Germany
This study demonstrates the potential of resting state functional magnetic resonance imaging for investigating the mouse brain functional networks in normal and pathological conditions. We investigate the impact of experimentally induced demyelination on the functional connectivity of cuprizone demyelinated mice. Data derived from independent component analysis combined with partial correlation analysis and graph theory indicate a complex remodeling of the large scale functional networks in the mouse brain as an effect of demyelinating pathology.