Wei-Feng Hung1, Po-Tsun Chen1, Tzu-Chao Chuang1, Hing-Chiu Chang2, Ming-Ting Wu3, 4
1Department of Electrical Engineering, National Sun Yat-Sen University, Kaohsiung, Taiwan; 2Brain Imaging and Analysis Center, Duke University, Durham, NC, United States; 3Department of Radiology, Kaohsiung Veteran General Hospital, Kaohsiung, Taiwan; 4School of Medicine, National Yang-Ming University, Taipei, Taiwan
MP2RAGE, which collects two volumes at different inversion times, can be applied for volumetric T1 mapping because the relationship between T1 and the ratio of two gradient echoes can be derived with a known inversion efficiency of adiabatic pulse. However, the over-estimation of inversion efficiency, which was simulated according to pulse profile, may lead to under-estimation of T1. An improved sequence, MP3RAGE, was developed to acquire data at three distinct inversion times, taking inversion efficiency as a free parameter to estimate T1 relaxation time more accurately.