Zhuozhi Dai1, Jim Ji2, Gang Xiao3, Gen Yan1, Zhiwei Shen4, Guishan Zhang1, Lvhao Wang1, Phillip Zhe Sun5, Renhua Wu1
1Medical Imaging, Medical College of Shantou University, shantou, guangdong, China; 2Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, United States; 3Hanshan Normal University, Chaozhou, Guangdong, China; 4the provincial key laboratory of medical molecular imaging, Shantou, Guangdong, China; 5Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, MGH and Harvard Medical School, Charlestown, MA, United States
CEST MRI is a relatively new contrast mechanism that is promising for clinical translation in a host of diseases including stroke, tumor and multiple sclerosis. However, the conventional CEST MRI requires significant sequence development and is susceptible to field inhomogeneity-induced distortion at high field. To address these limitations, we evaluated the magnetization transfer prepared gradient echo (MTPGE) MRI for CEST imaging. We validated and optimized the proposed MTPGE in creatine-gel phantom, and demonstrated the endogenous amide proton transfer (APT) MRI in vivo.