Axel J. Krafft1, Brian Allen Taylor1, Hannah Lin1, 2, Ralf B. Loeffler1, Claudia M. Hillenbrand1
1Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States; 2Rhodes College, Memphis, TN, United States
Iron overload assessment is one of the most prominent applications of multi-echo GRE-based quantitative T2* mapping. One of the major confounding factors arises in the presence of fat due to additional modulations of the mGRE signal. However, these modulations can be modeled and have led to dedicated techniques for fat-water quantification with T2* estimation. Here, we systematically analyze a recently proposed autoregressive moving average (ARMA) model for its ability to simultaneously quantify fat-water concentrations and the associated T2* times. The ARMA model is compared to conventional fitting approaches and evaluated in phantoms and volunteer data.