Anthony J. Romano1, Michael Scheel2, Sebastian Hirsch3, Juergen Braun4, Ingolf Sack2
1Physical Acoustics, Naval Research Laboratory, Washington, DC, United States; 2Department of Radiology, Charite-Universitatsmedizin, Berlin, Germany; 3Department of Radiology, Charit - Universittsmedizin Berlin, Berlin, Germany; 4Institute of Medical Informatics, Charite - University Medicine Berlin, Berlin, Germany
White matter is composed primarily of myelinated axons which form fibrous, organized structures and can act as waveguides for the anisotropic propagation of sound. The evaluation of their elastic properties reguires both knowledge of the orientation of these waveguides in space, as well as knowledge of the waves propagating along and through them. Here, we present waveguide elastography for the evaluation of the elastic properties of the Corona Radiata, In Vivo, using a fusion of MRE, DTI, and anisotropic inversions. It is shown that the Corona Radiata can be characterized by Orthotropic anisotropy.