Maximilian Freiermuth1, Linus Willerding2, Maximilian F. Reiser1, Michael Peller1, Olaf Dietrich1
1Josef Lissner Laboratory for Biomedical Imaging, Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Munich, Germany; 2Department of Internal Medicine III, Ludwig-Maximilians-University Hospital Munich, Munich, Germany
The purpose of the present study was to optimize and evaluate a fast three-dimensional T1 mapping approach based on the variable flip angle (VFA) technique. The proposed method requires only a single 3D FLASH data set for each time point combined with a longer baseline measurement. The optimal flip angle for the dynamic series can be shown to be α dyn,opt = arccos[(2E11)/(2E1)], which was also confirmed experimentally. The proposed single-flip-angle technique provides accurate T1 values (within 5%) in phantom measurements.