Jeam Haroldo Oliveira Barbosa1, Saifeng Liu2, Jin Tang3, Manju Liu4, Weili Zheng4, Ewart Mark Haacke2, 4, Carlos Ernersto Garrido Salmon1
1Department of Phisics, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil; 2School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada; 3MRI Institute for Biomedical Research, Detroit, MI, United States; 4Wayne State University, Detroit, MI, United States
There are a variety of means by which iron content in vivo tissue can be measured. These include but are not limited to measuring: transverse relaxation rates (R2 and R2*) and quantitative magnetic susceptibility (QSM). However, the dependency of transverse relaxation rates with water content can confound the accuracy of iron quantification if R2 or R2* are used. To overcome this limitation, magnetic susceptibility mapping has been suggested to evaluate iron deposits in neurodegenerative diseases. In this study, we evaluated the correlation between iron concentration with R2 and R2* and magnetic susceptibility in vivo in the midbrain region for seven healthy elderly subjects.