Xia Jiang1, Hanbing Lu2, Shuichi Shigeno3, Li-Hai Tan4, Yihong Yang5, Clifton W. Ragsdale3, Jia-Hong Gao1
1Brain Research Imaging Center and Department of Radiology, University of Chicago, Chicago, IL, United States; 2Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, United States; 3Department of Neurobiology, University of Chicago, Chicago, IL, United States; 4State Key Lab for Brain Research, University of Hong Kong, Hong Kong, China; 5Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore,, MD, United States
Much effort has been made to determine the feasibility of neuronal current MRI (nc-MRI), where the small magnetic field change due to neuronal currents activity is mapped using MRI. However, most previous studies in nc-MRI were susceptible to the contamination of BOLD signal. In this study we tested nc-MRI in the octopus visual system, which is free from BOLD effect. In addition, electrophysiological recordings were used to confirm electrical activities. Scans with the EPI sequences indicated that no statistically significant nc-MRI effect could be detected at 0.2%/0.2&[deg] level for signal magnitude and phase respectively.