Hyungseok Jang1, Sankaran Subramanian2, Nallathamby Devashayam2, Murali C. Krishna2, Alan B. McMillan1
1Radiology, University of Wisconsin, Madison, WI, United States; 2Radiation Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, MD, United States
In EPRI acquired using single-point techniques, repeated imaging experiments with differing gradient amplitudes are used to calculate spectral linewidths necessary to quantify pO2. In this study, we propose a novel estimation method that enables direct calculation of linewidth within a single dataset. We investigate gridding reconstruction and image-based registration techniques to maintain image FOV, and enable pixelwise estimation of linewidth. In phantom experiments, we show that these methods allow quantification of pO2 within a single dataset, which will allow temporal resolution improvements of 3x compared to existing techniques.