Rebecca S. Samson1, Nils Muhlert2, Varun Sethi2, Claudia Angela M. Wheeler-Kingshott2, Maria A. Ron2, David H. Miller2, Declan T. Chard2
1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, England, United Kingdom; 2NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom
Histopathology has demonstrated extensive cortical grey matter (CGM) demyelination in multiple sclerosis (MS), and suggests that sulcal folds may be preferentially affected, particularly in secondary progressive (SP) MS. We measured sulcal and gyral crown magnetisation transfer ratio (MTR) in MS and healthy control CGM in vivo, and examined associations with clinical status. CGM MTR abnormalities were present in all MS subtypes and were most pronounced in SPMS. However, sulcal was lower than gyral MTR in all groups (including controls) except SPMS, indicating that there is not a clear sulcal predilection for these changes.