Tao Jin1, Seong-Gi Kim1
1Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States
In CEST studies, the off-resonance irradiation power amplitude (B1) should be adjusted to optimize the sensitivity and/or specificity of chemical exchange contrast. If only one type of labile proton exist or is dominant, B1 can be optimized to maximize the sensitivity of chemical exchange contrast. If several types of labile protons have similar Larmor frequencies but very different exchange rates, B1 can also be optimized to selectively enhance the chemical exchange contrast from a specific labile proton. In this work we derived analytical solutions for B1 optimization of these two cases in the slow exchange regime.