Lindsey Alexandra Crowe1, Azza Gramoun1, Wolfgang Wirth2, Frank Tobalem3, Kerstin Grosdemange4, Jatuporn Salaklang5, Anthony Redgem5, Alke Petri-Fink6, Felix Eckstein2, Heinrich Hofmann7, Jean-Paul Valle1
1Radiology / Faculty of Medicine, Geneva University Hospital, Geneva, Switzerland; 2Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria; 3Radiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; 4Faculty of Medicine, University of Geneva, Geneva, Switzerland; 5Adolphe Merkle Institute, Universit de Fribourg, Fribourg, Switzerland; 6Adolphe Merkle Institute and Chemistry Departement, Universit de Fribourg, Fribourg, Switzerland; 7Institute of Materials, Powder Technology Laboratory, EPFL, Lausanne, Switzerland
We present quantification of inhomogeneous SPION uptake over a 3D volume using dUTE and customized software in a rat AIA model at 3T. The use of SPION as a contrast agent is leading development of image acquisition and analysis techniques to quantify uptake and persistence. As signal from iron oxide uptake in vivo can be inhomogeneous, quantification of both the volume and signal intensity are needed for the true extent of SPION uptake. Positive contrast dUTE imaging is used due to its concentration dependence of signal intensity for iron oxide containing regions along with validation of a semi-automated segmentation technique.