Yu Shao1, Peng Zeng2, Joseph Murphy-Boesch3, Jeff H. Duyn3, Alan P. Koretsky3, Shumin Wang1
1Electrical and Computer Engineering, Auburn University, Auburn, AL, United States; 2Mathematics and Statistics, Auburn University, Auburn, AL, United States; 3LFMI/NINDS/NIH, Bethesda, MD, United States
Local specific absorption rate analysis is critical to the safety of high-field human MRI studies. In order to address the inter-subject variability in head dimensions and the variability in the relative position of the human body to the RF coil, applying the conventional Monte Carlo method would require a fairly large number of simulations. In order to dramatically improve the efficiency of statistical simulations, we propose a new approach based on the Latin Hypercube Sampling (LHS). The LHS can achieve the same accuracy with much smaller run size than conventional Monte Carlo sampling because it guarantees that the selected runs uniformly spread across the domain of each input variable. We demonstrate that with a few sampling points (17 samples), the expectation, the standard deviation and sensitivity to changes in conditions, such as the head geometry and its relative position, can be accurately computed when six random variables were considered. This approach appears uniquely suited for RF safety assessment.