Chiara Mastropasqua1, 2, Marco Bozzali3, Viviana Ponzo4, Mara Cercignani, 15, Carlo Caltagirone6, 7, Livia Brusa8, Giacomo Koch4, 9
1Neuroimaging Laboratory, IRCCS Santa Lucia, Rome, Italy; 2Department of Neuroscience, Trieste University, Trieste, Italy; 3Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy; 4Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia, Rome, Italy; 5Clinical Imaging Sciences Centre, Brighton & Sussex Medical School, Falmer, United Kingdom; 6Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy; 7Dep. of Neuroscience, University of Rome Tor Vergata, Rome, Italy; 8Dep. of Neurology, S. Eugenio Hospital, Rome, Italy; 9Stroke Unit, Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
Progressive Sopranuclear Palsy (PSP) is a degenerative parkinsonism clinically characterized by postural instability and sopranuclear gaze palsy. Repetitive Transcranial Magnetic Stimulation (rTMS) shows promising results when used as a therapeutic tool. We investigated the impact of cerebellar iTBS on Functional Connectivity (FC) in a group of PSP patients comparing Resting State fMRI, before and after iTBS treatment.We found a bilateral increase in FC in the caudate nucleus and in left parietal cortex, and a FC reduction in the right precuneus, after iTBS treatment. Our study provides new evidence that iTBS is able to induce modifications of FC in PSP patients.