Laura Serra1, Lucia Fadda2, Roberta Perri2, Barbara Span1, Mario Torso1, Diana Castelli3, Camillo Marra3, Carlo Caltagirone2, Marco Bozzali4
1Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; 2Neurological and behavioural laboratory, IRCCS Santa Lucia Foundation, Rome, Italy; 3Institute of Neurology, Universit Cattolica, Roma, Italy; 4Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy
Using voxel-based morphometry we investigated the pathophysioological substrate of constructive apraxia (CA) in patients Alzheimer's disease (AD). A peculiar pattern of regional GM atrophy was present in those patients with CA manifestations but not in the others. Our findings fit well with current anatomo-functional theories on CA.