Abstract #2919

Assessment of Pharmacologically Induced Hypothermia Treatment in a Rodent Model of Focal Cerebral Ischemia by Using Diffusion Tensor Imaging

Silun Wang¹, Xiaohuan Gu², Ko-Eun Choi², Yumei Yan¹, Ling Wei², Shan-Ping Yu², Xiaodong Zhang¹

¹Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States; ²Department of Anesthesiology and Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States

We evaluated the pharmacologically induced hypothermia treatment response in focal cerebral ischemia induced white matter injury in a mice model using DTI. Results indicated that significantly reduced infraction volume in the treatment group compared to control group. Significantly decreased FA and λ// were only found in the ipsilateral external capsule and fornix than contralateral sides in control group. Less reduction of FA and λ// were found in the hypothermia treated group. Our results support the use of DTI as a biomarker to non-invasively monitor the hypothermia treatment response in ischemia induced stroke injury.