Qiang Shen1, Fang Du1, Shiliang Huang1, Yash Vardhan Tiwari1, Timothy O. Duong2
1Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; 2Research Imaging Institute, UT Health Science Center at San Antonio, San Antonio, TX, United States
We evaluated the initial lesion volume 30 mins after stroke and infarct volume at day 2 for multiple middle cerebral arterial occlusion (MCAO) durations in rats. Our results showed that the infarct volumes at day 2 were smaller than the initial lesion volumes at 30 mins after MCAO in 30- and 45-min MCAO groups but larger in 60- and 90-min groups. In the 30-min MCAO group, half the initial ADC lesion was reversed, whereas in the 60- and 90-min MCAO groups, only about 10% of the initial ADC lesion was reversed, and there was a weak dependence on duration.