Alexander Radbruch1, 2, Johanna Mucke1, Markus Graf2, Ralf Floca2, Matthias Roethke2, Heinz-Peter Schlemmer2, Sabine Heiland1, Martin Bendszus1, Stefan Rohde1
1Department of Neuroradiology, Heidelberg University Medical Center, Heidelberg, Germany; 2Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
The penumbra concept based on MRI diffusion and perfusion imaging is frequently used within clinical practice. However, it has become under debate since perfusion MRI is supposed to overestimate the tissue at risk. Susceptibility Weighted imaging provides an alternative method for penumbra determination due to the appearance of hypointense vessels within the hypoxic area. In our study we compared the penumbra determined by either SWI or time to peak perfusion (TTP) maps and found the penumbra determined on SWI to be significantly smaller than TTP maps (p<0.0001). Hence SWI may determine the penumbra more accurately than TTP maps.